Starring real life couple, Lucille Ball and Desi Arnaz, I Love Lucy was a trailblazer of sitcoms, changing the course of TV history, while making audiences laugh their pants off all the while. With Season One airing in 1951, it was the first show to be filmed in front of a live-studio audience and the three-camera set up. Lucille Ball broke social norms, and was the first actress to play a pregnant woman while pregnant. Lucy and Ricky were also the first interracial TV couple and their production company, Desilu Productions, went on to define the modern sitcom in many ways. The show remains one of the funniest shows of all time, still enjoyed by an average of 40 million people each year—which is why there are countless memes and gifs to enjoy.